In the season opener, the Madonna women's basketball team secured a decisive victory over Great Lakes Christian College on October 28, 2025. The event, an out-of-conference regular season game, was held at the Doty Center in Lansing, Michigan.

The Crusaders, led by a stellar performance from Lizzy Liedel who scored 21 points alongside recording 8 steals, showcased their dominance right from the start. Pierce Cephas and Faith Jungwirth also contributed significantly, with Cephas adding 14 points and Jungwirth 13. The team's combined effort resulted in a dominant first half, closing at 47-29 in favor of Madonna.

Other key stats included efficient teamwork, with Breanna Gamble leading in assists, contributing 5 of the team's advances. Terre'ya Moore not only added 9 points but was also a major force defensively, grabbing 9 rebounds. The defensive efforts were complemented by robust offensive execution throughout the game.

As the game concluded, the Crusaders had extended their lead to secure a 91-66 victory, opening their season with a record of 1-0. This game further emphasized their capable roster and strategic depth, hinting at a promising season ahead. The team is scheduled to face St. Clair College next on November 4, 2025, at the SportsPlex Gymnasium in Windsor, Ontario, as they aim to build on their successful start. Madonna University is set to tip-off against St. Clair College at 5:00 PM.